Expression of apoptosis-related proteins bcl-2 and bax in tumor infiltrating dendritic cells in human endometrial cancer
نویسندگان
چکیده
The purpose of this study was to investigate changes in apoptosis-related proteins bcl-2 and bax on tumor infiltrating dendritic cells (TIDCs) in human endometrial cancer. Expression of bcl-2 and bax proteins in TIDCs of 52 patients with human endometrial cancer were studied by double-labeling immunehistochemistry and image analysis, respectively. 28 cases of normal endometria served as control. DCs in these specimens were labeled by S-100 monoclonal antibody. Statistically significant differences (P<0.05) in bcl-2 and bax proteins expression were noticed on TIDCs in human endometrial cancer when compared to normal endometrium. The levels of expression of bcl-2 on TIDCs in human endometrial cancer were significantly lower compared to those on DCs in normal endometrium (P<0.05). The intensity of bax on DCs was considerably higher in human endometrial cancer compared to that in normal endometrium (P<0.05). Taken together, the data suggest that those apoptosis-related proteins bcl-2 and bax on TIDCs in human endometrial cancer are unbalanced. Therefore, the changes may lead to the occurrence of tumor immune escape, which promotes the evolution of endometrial cancer.
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